How does each pickup setup work and what setup is better for what kind of sound? What I mean is whats the difference between a humbucker-humbucker, single-single-humbucker and single-single-single in terms of sound?
A single has a more raw sound, and it hums. Humbuckers tend to give more warmth IMO. Thats why you dont see many metal players playing a strat (Yes, I know, Iron Maiden) but for tones like Lamb of God or Amon Amarth you pretty much need a humbucker equipped guitar. If you have both single coils and humbuckers in a guitar then you basically have more versatility.