#1
...i were to remove the pickup covers from the humbuckers of an Epiphone Dot? would it change the sound any?
Gibson Les Paul Studio
Squier Classic Vibe Tele
Fulltone Clyde Wah
Fulltone OCD
Fulltone Deja Vibe
Fuzz Factory
Carbon Copy

Boutique Marshall-Style 50watt amp head
Orange 2x12
#2
Not really, pickup covers have a VERY minuscule effect on sound.
Guitars
Agile 3100 CSB
ESP MH400 w/ Trem-Setter
Epi G-310
Applause Acoustic

Amps
1968 Fender Vibrochamp - Great amp, only $100 fixxer-upper
Line 6 Spider II

REMEMBER, ALL TONE IS SUBJECTIVE!
#4
Maybe just a mini bit, but almost impossible to tell.
Unless you are a great BS'er like Eric Johnson.