#1
is there much difference between a 12" radius and a 9.5" radius on a strat neck??

i know there will be a difference to a certain degree but how much exactly? (dont say 2.5"s smarty pants people)

how does it affect chording etc etc.

cheers.
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#2
Chording is going to be easier on the 9.5 and string bending is going to be easier on the 12.

I think it's a very noticeable difference (Most old-style Fenders are around 9 while most Tune-O-Matic bridged guitars are around 12 if you need to find something to compare).
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^I'd let a pro look at it. Once you get into the technicalities of screws...well, it's just a place you don't want to be, friend.