I think you can just pull them off, or there's a screw that you need to take the pickguard off to get to.
Max, you don't need to take the pickguard to get to the screw that locks the dome-type knobs in place.

Strat knobs pull off. They may be on pretty snug, so you should wrap a t-shirt around the knob, including the bottom, and just pull.
Will says:
- SmarterChild - says:
I don't know if I can help it.

Member #6 of the "I play my guitar as high as Tom Morello does" club
pull them. If they don't go easily, take a strip of cloth and force it underneath, wrap and pull.
I removed them with the shirt method but dude.... they were SO damn tight...

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yea.. but dont do the string-to-the-door-dog-pull thing otherwise bye-bye Strat...pull in a circular motion(right to left) should do the trick