I just bought a 212 yesterday, and it is pretty awesome for what I play (Death Metal). I havent tried GnR because I don't ever play them...but I dont see why not.
Schecter C-1 Classic
LTD EC-1000
Fender American FSR Mahog. Chambered Tele 60th
Fender Mexican Strat SD Hot Rails Br/Ne
Fender Hot Rod Deville 4x10
Boss DD-6
Boss Metal Zone
Its a fairly versatile amp, in my experience, you should be able to mostly what you want out of it with some tweaking.