#2
when you have your left hand at an angle (Like Clapton or Hendrix), you eliminate the ability for your pinky finger to be used on the low strings.
Cream fan club member #11.
#3
I find it easier to play with my fingers slightly angled because I have huge hands, it's difficult to fit them all in on high frets if I keep them parallel with the fret wire.
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#4
Ok, but my hand tend to "straighten out" the closer to the 6th string i get, so maybe it's not a huge problem...

Keeping my hand straight at high frets also causes my wrist to tense up quite a lot... I guess i'll stick with playing with an angle at the thin strings and straight at the thick ones.
#5
I use my thumb alot all hendrix style it works for me but eh.
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Holy Knight of the Crusading Order of the Stratocaster.

Gear:
MIA Fender Stratocaster
MIA Fender Telecaster
MI? Fender TC-90

Fender Hot Rod Deville
Blackstar HT5, HT40

various pedals