#2
You'll have to adjust your intonation. If you have a tremolo, you'll have to add springs in the back, too.
My League of Legends stream
The morning will come
In the press of every kiss
With your head upon my chest

Where I will annoy you
With every waking breath
Until you, decide to wake up
#3
Yeh, intonation, tremelo tension if applicable, and with such a guage jump it is recommended that you give your neck a bit of a tweak, there will be a noticable backbow which is better off fixed than left. Also, flog the hell out of your fingers untill they adjust to the guage, it takes probably a solid week to beef up callisses