I was wondering if the pedal that comes with GR2 is a must for GR2 to work. My problem is that GR2 isn't picking up any sounds from my guitar.

Guitar > Marshall MG > MG's line out to Computer Microphone

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Yamaha RGX220
Peavey 5150
Trohak Cabinet (w/ Eminence speakers)
Mesa/Boogie 2x12 Roadster
Marshall Mg15
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the microphone is the worst way to input a signal, the latency is really bad on the mic in jack, especially with all the modeling, equalizing and stuff done to that signal.

Use the pedal board, the whole point of guitar rig is so that you don't need an amp and pedals.
Peavey 5150
Mesa Mark IV
Mesa Single Rectifier (Series 1)
Fender Custom Shop Tonemaster
Roland Microcube

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