i was wondering if it was possible to run the ns-2

Guitar -> ns2 input-> Ns2 output-> to amp

Effects loop in-> Send of Ns2-> Return of Ns2 -> return of effects

or will that **** things up?

is it better to run the ns-2 through the effects loop? i mainly use the amps overdrive and i use a ts9 as a boost.

Guitars- Gibson SG Stanadard (stock)
Epiphone Les Paul Custom Emg 81/85

Amp- Marshall Jcm 2000 DSL/1960 Lead Cab

Pedals- Boss TU-2, Ibanez TS-9, Boss NS-2, Line 6 DL-4, Boss Ph-3, Boss GE-7
my buddies and i only run our noise supressor direct and never through the effects loop.

We might have been effing up all along though.
My Gear:
Gibson SG special (W/ S.D. Jazz(N) & JB (B))
Mesa-Boogie Solo Triple Rec. (with EL-34's)
Boss DD-6 Digital Delay
Boss TU-2 Chromatic tuner
(what else do i need)

Where i work:
Depends, I use a Decimator before the amp, but then I figured out that it was my guitar's wiring gone to crap that was causing noise. Try it in both, and see what works best.
Peavey 5150
Mesa Mark IV
Mesa Single Rectifier (Series 1)
Fender Custom Shop Tonemaster
Roland Microcube

-Whitebox OS 1x12
-Port City OS 1x12

Digidesign Eleven RackAxe Fx Ultra