On my high e string, the screw that goes down toward the guitar on the bridge, ( last screw down ) is coming up and the high e string buzzes now.

What do I do?
i would guess you go have it fixed or fix it yourself. i would suggest a guitar shop though.
Are you talking about the height adjustment screw or the intonation screw. On LPs there are 2 height adjust screws and strats have 1 or 2 for each saddle they run perpendicular to the body. The intonation screws run parallel to the guitar body. If its just the adjustment screw backing out screw it back in.