Imagine u won the lottery or something and u could get any guitar amp effects anything related to music. for me it would have to be American Deluxe Ash Stratocaster Electric Guitar and this amp =p Fender Twin Amp 100-Watt All-Tube Amp
This has been done a million times. But anyway, tis a tele or les paul, and a mesa amp, maybe a heartbreaker.
Custom shop Strat/Tele hybrid and Orange amp of some sort.
Kiko Loureiro's high end tagima series, customised to hell though