hey i was wondering

how would the Seymour Duncan STK-S2 sound in a fender strat hss? it would be in the neck and mid positions

and would it be a good combo with Seymour Duncan SH-5 Duncan Custom in the bridge?

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Fender Strat HSS
line6 spider III
Line6 Spider Valve HD-100
Dunlop Crybaby
Boss GT-10
Why the stacked single coil? Stacked single coils never measure up to real single coil tone, IMO.

I think a Duncan SH-11 Custom Custom would be better, personally...

What kind of music do you play?

Also...I hope you own a different amp than the Spider. If you're spending 120-250 bucks on pickups...You can surely save up for a better amp. Your amp is much more of an influence on your tone than your pickups.