i'm pretty sure it can't, you can just wipe it off, just clean it with a soft cloth
Generally i'd say no, but if you allow major dust build up until it becomes like a dirty scum on your guitar then yes.

If you let a guitar get that dusty, you don't deserve to own it though...
My Gear
Original JCM800
Fender Blues
ADA MP1 Rack

1952 RI Tele
Fender Floyd Fat Strat
Dean Razorback V255
Dean ML79F
Fender Strat, scalloped
Fender Floyd Strat
Ibanez RG550 - 1987 DY, 1990 DY, 2002 BK
Kramer Paul Dean
Danelectro DC59