For the past few days, I've taken to running my Mesa Mark IV's graphic EQ in something other than the v: 1 and 5 are maxed, 2 and 4 are cut slightly below half, and 3 is halfway in between. I've noticed that it lets me have chunky palm mutes but still has a nice middy sound; check out the high gain clip on my profile for an example (though recorded with my laptop's internal mic). I personally like it loads better than the v.
Thoughts? Does anyone else use this kind of configuration?