I have the following pedals:

All Boss:

MD-2 Mega Distortion
TU-2 Tuner
SD-1 Super Overdrive
CH-5 Chorus Ensemble
NS-2 Noise Suppressor
CS-3 Compression Sustainer

Opinion on the best way to set this sucker up.

I curently have it: Guitar to Tuner, Tuner to Noise Sprsr. Noise Sprsr to Amp

In the Noise Sprsr Loop: 1st MD-2, 2nd SD-1, 3rd CH-5, 4th CS-3

I'm not sure if this is the most efficient way to do all this or even if there is a specific order I should have within the loop itself?

Any help would be great,
i would do this MD-2 > CS-3 > CH-3 > SD-1

normally people put compression first since it is honored for its clean sound. i like hearing chorus before fuzz. of course no one cares more about their timbre more than the guitarist playing it. take a couple hours trying out all 24 setup permutations.