Can incorrectly setting up an effects loop, or setting it up while the amp is on harm the amp in any way?

if you have any doubts see if you can find the manual for your amp on the interwebz somewhere. thats what i did for mine.
Quote by Peradactyl
alright, off topic but how do i make forum posts

Quote by The_Paranoia
a4lrocker is an offical thread legend.
I checked the manual, it didn't go very in depth about it.

I can run a wire from SEND to RETURN safely correct? I want to see if that solves any problems.