pretty much just plug it in to your amp. Its just like any other effects unit.
Ibanez SR-500
Schecter C1 Blackjack
Ibanez GSR200
Classical acoustic

G&K Backline 600 + Goldline 210GLX cab
Vox AD30VT
Crate G40C XL
Crate BT15
EH Metal Muff
Digitech Grunge
Danelectro Fab Overdrive
M-Audio Ozonic
Tascam M-308
U just need a guitar and a speaker....and as u said, u can use the amp's speaker. I got a Pod XT and a Cube 30x which is on clean and works as a speaker.....all the distortion and effects are controlled from the Pod..... and if im not wrong the V-Amp works just the same
what i do like about those amps...that u have a multitude of tones to choose from, and for 99$ go for it