I'm looking for some good funk amp settings for guitar, not bass. Sort of like a Wild Cherry "Play that Funky Music" to "Le Freak" kind of thing.

I realize there's the Ultimate Settings threads, but those defeat the purpose of the second half of the thread (posting settings and getting your questions answered), there is too much asking for settings and random settings (though they can be useful), and I've had a question or two up there for around a month.
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If you haven't already found a good amp setting after a few minutes' experimenting, don't expect to (unless you're a Mark IV owner...). Most of the tone is dependant on the gear.

Generic funk tonestend to be singlecoil into a clean or slightly dirty amp, with plenty of treble and presence and a tight bass.