Quote by kidsthesedays
^ yea they would. F is the IV and Eb is the V.

wouldn't it be the opposite?
You could substitute some of the chords to make it more interesting. For example, put a B chord in place of a F7 chord, or an F#maj7 in front of an F7.
A regular 12-chord progressioned blues in Bb would be:
Bb | Bb | Bb | Bb | Eb | Eb | Bb | Bb | F | Eb | Bb | Bb |

Also read like:
Bb x4, Eb x2, Bb x2, F, Eb, Bb x2.

But as blue_strat said: You could change them for substitutes.
Try like replacing Eb with Cm or F with Dm. ^^