#1
My friend informs me that his interface has a TRS out and his Monitors have both balanced XLR and TRS inputs. He uses TRS to XLR cables to connect his monitors to his interface though. Is there any advantage in doing that over just using balance TRS to TRS cables?
My Gear:

Schecter Hellraiser C-1 FR (EMG 85/81)
Mesa Boogie Stiletto Deuce
LOPO Custom 2x12 (Celestion V30s)
#2
No. Both are balanced signals and will have the same noise floor and levels regardless of which connectors are used.