Best heard from 0:02-0:10. What effects/settings/gear should one use to get that sound?
Sounds just like a slightly overdriven guitar with single-coils to me. Doesn't really sound like he's got any effects. There's a little bit of wah towards the end.
I think he means what comes before that.
I'd say a fairly bright sounding guitar (strat, tele - anything with single coils) and an amp with a good clean sound that is starting to break up.
uhhh turn up the drive alitte, sounds like hes using bridge pick up