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Scientists at Wake Forest University Baptist Medical Center are about to embark on a human trial to test whether a new cancer treatment will be as effective at eradicating cancer in humans as it has proven to be in mice.

The treatment will involve transfusing specific white blood cells, called granulocytes, from select donors, into patients with advanced forms of cancer. A similar treatment using white blood cells from cancer-resistant mice has previously been highly successful, curing 100 percent of lab mice afflicted with advanced malignancies.

Zheng Cui, Ph.D., lead researcher and associate professor of pathology, will be announcing the study June 28 at the Understanding Aging conference in Los Angeles.

The study, given the go-ahead by the U.S. Food and Drug Administration, will involve treating human cancer patients with white blood cells from healthy young people whose immune systems produce cells with high levels of cancer-fighting activity.

The basis of the study is the scientists' discovery, published five years ago, of a cancer-resistant mouse and their subsequent finding that white blood cells from that mouse and its offspring cured advanced cancers in ordinary laboratory mice. They have since identified similar cancer-killing activity in the white blood cells of some healthy humans.

"In mice, we've been able to eradicate even highly aggressive forms of malignancy with extremely large tumors," Cui said. "Hopefully, we will see the same results in humans. Our laboratory studies indicate that this cancer-fighting ability is even stronger in healthy humans."

The team has tested human cancer-fighting cells from healthy donors against human cervical, prostate and breast cancer cells in the laboratory – with surprisingly good results. The scientists say the anti-tumor response primarily involves granulocytes of the innate immune system, a system known for fighting off infections.

Granulocytes are the most abundant type of white blood cells and can account for as much as 60 percent of total circulating white blood cells in healthy humans. Donors can give granulocytes specifically without losing other components of blood through a process called apheresis that separates granulocytes and returns other blood components back to donors.

In a small study of human volunteers, the scientists found that cancer-killing activity in the granulocytes was highest in people under age 50. They also found that this activity can be lowered by factors such as winter or emotional stress. They said the key to the success for the new therapy is to transfuse sufficient granulocytes from healthy donors while their cancer-killing activities are at their peak level.

For the upcoming study, the researchers are currently recruiting 500 local potential donors who are 50 years old or younger and in good health to have their blood tested. Of those, 100 volunteers with high cancer-killing activity will be asked to donate white blood cells for the study. Cell recipients will include 22 cancer patients who have solid tumors that either didn't respond originally, or no longer respond, to conventional therapies. The study will cost $100,000 per patient receiving therapy, and for many patients (those living in 22 states, including North Carolina) the costs may be covered by their insurance company. There is no cost to donate blood. For general information about insurance coverage of clinical trials, go to the American Cancer Society's web site at www.cancer.org/docroot/ETO/content/ETO_6_2x_State_Laws_Regarding_Clinical_Trials.asp.)

For more information about qualifications for donors and participants, go to www.wfubmc.edu/LIFT (Web site will be available the evening of 6/27.) Cancer-killing ability in these cells is highest during the summer, so researchers are hoping to find volunteers who can afford the therapy quickly.

"If the study is effective, it would be another arrow in the quiver of treatments aimed at cancer," said Mark Willingham, M.D., a co-researcher and professor of pathology. "It is based on 10 years of work since the cancer-resistant mouse was first discovered."

Volunteers who are selected as donors – based on the observed potential cancer-fighting activity of their white cells – will complete the apheresis, a two- to three-hour process similar to platelet donation, to collect their granulocytes. The cancer patients will then receive the granulocytes through a transfusion – a safe process that has been used for more than 30 years. Normally, the treatment is used for patients who have antibiotic-resistant infectious diseases. The treatment will be given for three to four consecutive days on an outpatient basis. Up to three donors may be necessary to collect enough blood product for one study participant.

"The difference between our study and the traditional white cell therapy is that we're selecting the healthy donors based on the cancer-killing ability of their white blood cells," said Cui. The scientists are calling the therapy Leukocyte InFusion Therapy (LIFT).

The goal of the phase II study is to determine whether patients can tolerate a sufficient amount of transfused granulocytes for the treatment. Participants will be monitored on a regular basis, and after three months scientists will evaluate whether the treatment results in clear clinical benefits for the patients. If this phase of the study is successful, scientists will expand the study to determine if the treatment is best suited to certain types of cancer.

Yikong Keung, M.D., a medical oncologist, is the chief clinical investigator of the study. Gregory Pomper, M.D., assistant professor of pathology and the director of the Wake Forest Baptist blood bank, will oversee the blood banking portion of the study.


http://www.scientificblogging.com/news_releases/cancer_cured_granulocytes_treatment_worked_100_percent_in_mice_work_but_will_it_work_in_humans
Rig:

Gibson ES-335
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#3
Bs.
Quote by FrenchyFungus
I am not a woman as I currently claim


Quote by Rabid
I am actually a woman, unlike Frenchy
#4
they're not going to cure cancer.

THEY'RE NOT GOING TO CURE CANCER!

even if they can, which they can, they won't.
#DTWD
#5
Quote by bob farrell
Bs.



+1! I'm not taking it if they shove that bull**** at me! I don't want the world to end up like in I am Legend! Will Smith? Will you save us????

P.S.-

They said they found a cure for cancer like a couple of years ago, and it turned out to be ****.
#6
you're kidding
Your dreams are all out of focus;
Knock you up when you're feeling down.
And all the world feels so unreal...


COLORFUL COLORS
Quote by ishmonkey
Hitler was really smart and could have been a good leader but he was kind of a douche to the Jews.
#7
Quote by VivaLaJam
I am legend.

****ing beaten to it
Quote by Dillona
I think I want to have sex with you.

On topic: No, I haven't met any famous artists.


ofcourse i laughed xD

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yeah we're all dead now. Turns out we've been in hell all along.

About the LHC

#8
Brilliant!!!
Hull City A.F.C

Quote by Thrashtastic15
crunkym toy diuckl;ess ass ****igkjn ****** **** bitch ass pussy ****er douchecanoe ****** **** you s omn cnt you lieet le biutch
#9
I hope they don't find a cure.
Sunn O))):
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#10
There will NEVER be a one drug cure for all cancers.

They all have different patterns of mutations that result in unregulated cell proliferation, there'll never be a treatment that can handle every type of cancer.
#11
You cant really 'cure' cancer, you can only 'eradicate' it, and if eraditicating it constitutes as a cure, we've had the cure for years, radiation.
#13
Only Chuck Norris's tears cure cancer. But...

**** man this better not be real. I dont wanna put up with some kind of I am Legend ****!
#16
Quote by VivaLaJam
I am legend.


What I thought.
Quote by HuckIt
I didn't find it that funny when I saw myself doing him in missionary position...

Quote by Oblivion_Rps
I was having sex with a female dolphin. In the dream I was like:
"YEEEEEEEAAAARGH I'M SCREWIN' A FEMALE DOLPHIN!!!" and when I woke up I was like:
"... wtf"
#18
i think one day it will be cured. This could be it, but somehow I doubt it.

Imagine if I am legend did happen tho!
Quote by roythereaper
Nice bum >.> <.<
#19
Quote by Anthony1991
You cant really 'cure' cancer, you can only 'eradicate' it, and if eraditicating it constitutes as a cure, we've had the cure for years, radiation.
Well a safe treatment would be nice.
#20
Smells like some hardcore I Am Legend to me, but then again, how was it that they did it in teh movie? If i remember correctly it didnt have something to do with white blood cells did it?
Quote by I.O.T.M
Taking the piss out of Americans is like bullying retards, it's unashamedly one-sided but extremely gratifying.
#21
Let's think, kiddies. This isn't a cure for cancer by a long shot. It's shown (not proven) to be effective in mice (not humans). They're now undergoing a trial to investigate the possibility of a similar effect in humans. If this trial is effective, it'll undergo peer review for a long time. Then it'll undergo some actual clinical trials. Then it'll take years to turn into a medicine, then it'll take a damn long time for insurance to cover it. It's not a cure.

EDIT: Also, anyone who actually believes movie science is an individual with no higher consciousness. I Am Legend won't happen. Viruses don't go from cancer killers to freaky vampire mutagens in one generation.
#22
I bet the cure for cancer is something extremely stupid, that nobody's ever thought of, like carrots. Eat three lbs. of carrots and your cancer is gone.
Oct. 20th, 2009: New guitar AND front row for Mars Volta.

Quote by denizenz
Is that a ukulele in your pants, or did you just rip ass to the tune of "Aloha Oi"?


I met Sonic Youth on June 30th, and Mars Volta on Oct 20th.
#24
Cool. Wishful thinking, but hopefully something will come of it.

Probably not though.
#25
I mean didn't they modify a cancer and then inject it into a human? With this cell stuff I don't think that anything can go wrong, but when you modify a virus it can mutate, this is only just having something fight the cancer, right?
Quote by I.O.T.M
Taking the piss out of Americans is like bullying retards, it's unashamedly one-sided but extremely gratifying.
#26
dont worry about cancer kids if Bird Flu has a human mutation we are all screwed
#28
Quote by Lasyk
Smells like some hardcore I Am Legend to me, but then again, how was it that they did it in teh movie? If i remember correctly it didnt have something to do with white blood cells did it?


they reverse engineered aids
#29
Quote by tuwyci
dont worry about cancer kids if Bird Flu has a human mutation we are all screwed

Also not necessarily true. The plague in the Middle Ages was worse than anything modern science has seen so far, except for maybe AIDS.
#30
Quote by primusfan
they're not going to cure cancer.

THEY'RE NOT GOING TO CURE CANCER!

even if they can, which they can, they won't.


Shall I put my tinfoil hat on?

Quote by freedoms_stain
There will NEVER be a one drug cure for all cancers.

They all have different patterns of mutations that result in unregulated cell proliferation, there'll never be a treatment that can handle every type of cancer.


Pfft, no not with that attitude Mr. Raincloud.
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#31
I think I'm going to watch 'I am Legend now'....
Quote by I.O.T.M
Taking the piss out of Americans is like bullying retards, it's unashamedly one-sided but extremely gratifying.
#32
Quote by cokeisbetter
Also not necessarily true. The plague in the Middle Ages was worse than anything modern science has seen so far, except for maybe AIDS.


Didnt read the post there. i didnt say it was the worst in human history
#34
Quote by tuwyci
dont worry about cancer kids if Bird Flu has a human mutation we are all screwed

If it becomes a pandemic, it will be a rather big issue. They are already trying to find a cure, which must be pretty tough lol. I saw a scientist at oxford yesterday saying that ITS GONNA KILL US ALL!!!
Quote by FrenchyFungus
I am not a woman as I currently claim


Quote by Rabid
I am actually a woman, unlike Frenchy
#35
Quote by tuwyci
Didnt read the post there. i didnt say it was the worst in human history

Well, I was more pointing out that the plague didn't screw us over then, so avian flu couldn't be that bad now.
#37
We all know the government already has the cure and aren't releasing it so they could get the money from the cancer funds for themselves...DUH
I want to go as far to the edge without going over. Out on the edge, you can see all kinds of different things.
#38
Quote by Anthony1991
You cant really 'cure' cancer, you can only 'eradicate' it, and if eraditicating it constitutes as a cure, we've had the cure for years, radiation.


That's like saying 'we've had a solution to world hunger for years; kill everyone living in poverty'.

Radiation damages ALL living cells. That's why the instrument that delivers the radiation has to be spinning so quickly, so that the other tissues around the tumour receive smaller doses of the radiation. And on top of that, ionizing radiation is one of the biggest causes of cancer. That's why radiotherapy is often a last resort.

EDIT: As far as the whole Bird Flue thing goes, it's nowhere near as big a problem as the Plague was. The Black Death killed between 30% and 60% of everyone living in Europe at the time.
Last edited by burningcowsrule at Jun 29, 2008,
#39
Quote by burningcowsrule
That's like saying 'we've had a solution to world hunger for years; kill everyone living in poverty'.

Radiation damages ALL living cells. That's why the instrument that delivers the radiation has to be spinning so quickly, so that the other tissues around the tumour receive smaller doses of the radiation. And on top of that, ionizing radiation is one of the biggest causes of cancer. That's why radiotherapy is often a last resort.



Twas a joke. I was referring to the nutz who actually believe it.
I want to go as far to the edge without going over. Out on the edge, you can see all kinds of different things.
#40
Quote by soundgarden19
I bet the cure for cancer is something extremely stupid, that nobody's ever thought of, like carrots. Eat three lbs. of carrots and your cancer is gone.



that's what she said.
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