I'm pretty sure it will work.....but if will sound like ****.
American Strat:
Area 61 Neck, Area 67 Middle & Bridge
Spretzel Locking Tuners
Graphtech Nut & String Tree
Lots O' Love!

JSX + Orange Cab
Fender Blues Deluxe
Deluxe Memory Man
Fulltone Full Drive 2 & OCD
H2O Chorus/Echo
most line 6 cabs are voiced for their heads, so the frequency response is prolly a bit different, especially since they are modelers, so using a non-modelling head on the cab might not have the right frequency response your looking for. You should look at some avatar cabs, they are only slightly more expensive than that cab and have pretty good speaker options.
Modded Steinberger Spirit (white) (SD-AH/EMG Select)
Modded Steinberger GP-2R (white) (EMG81/60)
Peavey XXL head
Hughes and Kettner Cream Machine
Hughes and Kettner Blues Master