Does anyone know what amp settings to use (treble, middle, bass) for a sound close to that of the lead guitar of Dethklok?
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I'm not sure, but you could try

Treble - 10
Middle - 0
Bass - 10
Gain - 11

Seriously, start there and tweak around. Might need less bass and treble, depending on the amp. You might also want to creep up the mids, again that depends on your amp.

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its too metal too have amp settings
dont take any guff from these bastards man

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its too metal too have amp settings

and to what I hear, was done entirely on a Line6 Pod