Is it alright to put 2 different pickups for bridge and neck position in HSS configuration ?

Would it sound weird puting a vintage voiced one combined with a high output, metal voiced one ?

You'd have to watch out for the drop in volume because of the difference in output.

You can make it work, but it may be a hassle.
It will work but you'll have huge volume differences and your guitar will sounds completely different between pickups, I like having both pickups sounding like the same guitar. Just get some nice pickups and use pedals and your amp to get the gain. Also worry about how it will sound clean.
Gibson Les Paul Standard
Fender American 52 Telecaster RI
Fender American Standard Stratocaster
Tanglewood Acoustic
Fender F-80-12
Various Pedals
Orange Rockerverb 50 Head
Orange Cabinets