Check out some Audioslave stuff... Alot of it was actually done on a strat with basically the same setup (P/U wise), only Tom has Noiseless pups in the Neck/Middle....

So yes, only if you use the Middle and Neck p/u. Obviously, a wannabe humbucker aint a single.
Life is like an Empty Box, there could be something exciting in it at first look, but upon further review, well, it's empty.