So I set up my FX loop tonight thru the back of my amp, not just guitar to pedals, and everything was going great, then when I switched to my distortion it sounded very muddy, and my noise gate (Boss NS-2) was reducing anything. Help?
Try changing the order of the effects - some sound terrible in the loop, if your distortion is in the loop then I believe you'll have the preamp distortion battling with the pedal and giving you mud. The noise gate is moved around according to preference - mix and match.
+1 he's right
Quote by pedaler466
Shreadhead22 had nothing helpful to say to me. He just immediatly started being a prick.

Quote by Yngwi3
Shredhead's advice is the best in the thread.

-Mesa Roadster
-Mesa 4x12
-'93 Gibby LP studio
-EB volume
-Shure Wireless
Put your modulation pedals (phaser, flanger, delays etc.) in the loop - others like distortion, OD's, EQ's and noise gate go before the amp.
What amp are you using? I'm just asking because I'm experiencing EXACTLY the same problem with my VK when I throw my EQ in the loop.
-Ibanez ART 120 (w/EMG 81/85)
-Ibanez RG 1570
-Peavey 6505
-Tube-Town TTC 212V
-ISP Decimator G-String
-Maxon OD-9
-T-rex Fuel tank Junior

Coming soon:
-BBE Sonic Maximizer
THE IDEA of using an fx loop is to have your effects pedals work with the creamy goodness of a pre-amp tubes warmness.

instead of the low wave worm of a guitar you get the nice and wavy form of a tube getting passed into the effects pedals, which warms things up quite nicely.

HOWEVER, do not place anything in the fx loop that you wouldn't put AFTER a distortion pedal.

Things like delay work fine because delay 9 times out of 10 is used (and sounds good) after or with distortion, not the other way around (delayed sound into distortion is crap). However you wouldn't really put a wah in there. And even a phaser sometimes won't sound good.