David Byrne has warned Scottish people about the dangers of independence, saying that it "might be a bit much to handle."
As NME noters, an independence referendum will be held on September 18, which could see Scotland break away from the rest of the UK.
Byrne, who was born in Scotland and holds both a UK and US passport, gave his views on the Yes Vote in a new interview with the Evening Standard.
"As an outsider, my sense would be that by raising the issue again, Scotland can get a bit more autonomy and self-control, but complete independence might be a bit much to handle," he said. "I have lived in the States pretty much my whole life, but from my parents and everything, there's still an affinity to maybe a Scottish sense of humour, and some of the attitudes that go with that."
Earlier this year, the Rolling Stones' Mick Jagger and Sting were among a list of more than 200 famous faces who signed an open letter urging Scottish voters to keep Scotland as part of the United Kingdom.
David Bowie has also expressed his wishes for Scotland to stay with the UK.